Dr. Anthony Wynshaw-Boris is chief of Medical Genetics at UCSF Children's Hospital. He specializes in the treatment of genetic and metabolic disorders, including birth defects, mental retardation, familial heart disease, neurologic disorders and cancer.
Dr. Wynshaw-Boris earned a medical degree at Case Western Reserve University in Cleveland, Ohio. He completed a residency at the Rainbow Babies and Children's Hospital in Cleveland and a fellowship at Children's Hospital of Boston. In his research, he is interested in developmental neurogenetics and autism. He is a member of medical and scientific organizations including the American Society of Clinical Investigation, American Pediatric Society and Association of American Physicians. He is president of the Association of Professors of Human and Medical Genetics and a member of the board of directors of the American Society of Human Genetics. Dr. Wynshaw-Boris is a professor of pediatrics at UCSF.
Our research program focuses on understanding the genetic and biochemical pathways required for normal development and human genetic developmental diseases, primarily on pathways important for neurological development and neurogenetic diseases. The predominant approach is to produce and deploy mouse models to determine the specific in vivo requirements for pathways during development, and to utilize genetic, genomic, cell biological and biochemical tools to dissect these pathways in the developing animal. For many years, we have studied mouse models of human neuronal migration defects such as isolated lissencephaly sequence and Miller-Dieker syndrome as well as mouse mutants for each of three Dishevelled genes. These studies have provided important insights into the genetic factors and molecular mechanisms associated with neurological diseases. Recently, as part of an Autism Center of Excellence, we are examining genetic causes of brain overgrowth in autism spectrum disorders. |
Anthony Wynshaw-Boris, MD, PhD 
